What is a common side effect of taking long-term aspirin therapy?

Long-term aspirin therapy is often associated with gastrointestinal bleeding due to its antiplatelet effects. Aspirin inhibits the function of platelets, which can interfere with the blood clotting process and increase the risk of bleeding. Additionally, aspirin can irritate the gastric mucosa and contribute to the development of ulcers, which can also lead to bleeding. The risk of gastrointestinal complications is particularly concerning in individuals who have other risk factors, such as a history of peptic ulcers, concurrent use of other anticoagulants, or existing gastrointestinal disorders. Monitoring for signs of gastrointestinal bleeding is essential for those on long-term aspirin therapy.