What is considered the first-line treatment for generalized anxiety disorder?

The first-line treatment for generalized anxiety disorder (GAD) is selective serotonin reuptake inhibitors (SSRIs). SSRIs work by increasing the levels of serotonin in the brain, which helps improve mood and reduce anxiety. They have been extensively studied and are supported by clinical guidelines as effective for managing the symptoms of GAD.

SSRIs are generally preferred due to their favorable side effect profile compared to other medications. They are usually well tolerated by patients and carry a lower risk of dependence compared to benzodiazepines, which can be habit-forming if used over a prolonged period. Additionally, while atypical antipsychotics and beta-blockers may have some utility in specific situations or as adjunct therapies, they are not considered as primary treatments for GAD. Atypical antipsychotics are primarily used for mood disorders or psychotic disorders, and beta-blockers are more effective for situational anxiety rather than generalized anxiety. Therefore, SSRIs remain the cornerstone of pharmacological treatment for GAD.