Which symptom is most commonly associated with mononucleosis?

Severe fatigue is indeed the symptom most commonly associated with mononucleosis, often referred to as "mono." This viral infection, typically caused by the Epstein-Barr virus, is characterized by prolonged fatigue that can be overwhelming and persistent. Individuals with mononucleosis may find it difficult to engage in regular activities due to their extreme tiredness.

While joint pain, chest pain, and shortness of breath can manifest in various medical conditions, they are not hallmark symptoms of mononucleosis. The extreme fatigue that accompanies mono can significantly impair daily functioning, making it a defining feature of the illness. Understanding the primary symptoms of conditions like mono is crucial for accurate diagnosis and effective management.