Which two tests indicate a current Hepatitis B infection?

The presence of Hepatitis B surface antigen (HbsAg) and IgM antibodies against the hepatitis B core antigen (anti-HBc IgM) is indicative of a current Hepatitis B infection. HbsAg is the protein found on the surface of the hepatitis B virus, and its presence means that the virus is actively replicating in the body, thus indicating an active infection. In conjunction, the detection of IgM anti-HBc signifies that the infection is recent and is typically present during the acute phase of Hepatitis B infection.

The other tests mentioned in the options do not indicate a current infection effectively. For example, Hepatitis surface antibody and IgG are markers indicative of past infection or recovery, and viral load typically measures the quantity of virus in blood but isn't specific to determining the infection status by itself. HbsAg with anti-HBs indicates an active infection but also reflects recovery or immunity, which does not confirm a current infection on its own without the context provided by anti-HBc IgM.